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Six weeks after the third edition, the world has changed again.
The pandemic is raging in South America, particularly in Brazil,
Ecuador and Peru. SARS-CoV-2 is under control in China, but in
Iran it is not. And in Europe, where most countries have weathered
the first wave and open borders to save a compromised tourist season, is now wondering if and for how long this biological
drôle de guerre could last.

Science has moved ahead, too. We have seen a more complex
picture of COVID-19 and new clinical syndromes; the first data
from vaccine trials; first results from randomized controlled
drug studies; encouraging publications on monoclonal neutralizing antibodies and serological evidence about the number of people who have come into contact with SARS-CoV-2. Unfortunately, we have also seen the first science scandal with fake data published in highly ranked journals. And we face new challenges like long-term effects of COVID-19 and a Kawasaki-like inflammatory multisystem syndrome in children.

For quite some time, prevention will continue to be the primary
pillar of pandemic control. In future waves of the SARS-CoV-2
pandemic, we will focus on the conditions under which SARSCoV-
2 is best transmitted: crowded, closed (and noisy) places and
spaces. Although hospitals are not noisy, they are crowded and
closed, and the battle against the new coronavirus will be decided
at the very center of our healthcare system. Over the next
months and maybe years, one of all of our top priorities will be
to give all healthcare workers and patients perfect personal protective equipment.

Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. Despite drastic containment measures, the spread of this virus is ongoing. SARS-CoV-2 is the aetiological agent of coronavirus disease 2019 (COVID-19) characterised by pulmonary infection in humans. The efforts of international health authorities have since focused on rapid diagnosis and isolation of patients as well as the search for therapies able to counter the most severe effects of the disease. In the absence of a known efficient therapy and because of the situation of a public health emergency, it made sense to investigate the possible effect of chloroquine/hydroxychloroquine against SARS-CoV-2 since this molecule was previously described as a potent inhibitor of most coronaviruses, including SARS-CoV-1. Preliminary trials of chloroquine repurposing in the treatment of COVID- 19 in China have been encouraging, leading to several new trials. Here we discuss the possible mechanisms of chloroquine interference with the SARS-CoV-2 replication cycle.